This view of the beta chain shows charged amino acids, polar amino acids, hydrophobic amino acids, heme, and water oxygens. Charged and polar aa's are common on the surface, where they form hydrogen bonds with water (most water is not shown).

A vertical slice through the molecule, near the front surface, shows many hydrophilic residues.

As we move the slice plane deeper into the molecule, the center is hydrophobic while the surfaces have many polar and charged residues.

Near the rear surface, hydrophilic residues are again common.