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EUCIB Mouse Backcross Database
The EUCIB Mouse Backcross Database (MBx) was written to hold
experimental data derived from the EUCIB project. Searches are done on
copies of the database files which are updated overnight. The data is
displayed in a similar format to the retrieval forms of the Sybase
version of the database. Some of the data has restricted access.
Mouse Genome Informatics (MGI)
MGI is produced by the Jackson Laboratory, in Bar Harbor, Maine. This
is a copy at the HGMP for public use.
MGI is a comprehensive database of genetic information on the laboratory mouse. It includes:
The dysmorphic human and mouse homology database
This consists of three separate databases of human and mouse
malformation syndromes together with a database of mouse/human syntenic
regions. The mouse and human malformation databases are linked together
through the chromosome synteny database. The purpose of the system is
to allow retrieval of syndromes according to detailed phenotypic
descriptions and to be able to carry out homology searches for the
purpose of gene mapping. Thus the database can be used to search for
human or mouse malformation syndromes in different ways:-
Mouse Genome Informatics Project (Jackson Labs)
is maintained by Jackson Laboratory, in Bar Harbor, Maine. This site
holds much information on mouse genetics. It is the home site of MGD,
which is mirrored at the HGMP.
Genome Navigator: Whitehead/MIT Mouse Genome Map
Genome Navigator is an attempt to provide a visual interactive gateway
to major databases containing physical and genetic mapping information
about the mouse genome.
Genomic maps of these organisms are displayed using DerBrowser, a Java applet, designed as a universal tool to display and navigate various types of maps. Among other features, it allows a user to query external databases about any map object.
Gene Expression Database (GXD)
The GXD Index is an index of research reports documenting data on
endogenous gene expression during mouse development that have been
published from May 1993 to present.
The GXD Index includes references, genes and embryonic stages analyzed, and expression assays used, and enables database queries such as: What expression assays have been used to study the expression of a given gene, what stages of mouse development have been analyzed, and what references contain the respective data? Or: Tell me all the genes for which expression studies (or specific assays) have been done at a specific time period of mouse development.
The Gene Expression Database project aims for a comprehensive annotation of these expression data and for much more sophisticated storage, display and analysis tools (see online info).
The GXD Index is integrated with the Mouse Genome Database to foster a close link between genotype, expression and phenotype information.
RATMAP
is a database covering genes physically mapped to chromosomes in the laboratory rat. In
addition to chromosomal localisation of genes and anonymous DNA sequences, RATMAP gives
information about methods and accuracy of localisation (Mode and Status) and a short description of
the genes. Appropriate literature references to each mapped rat gene are also given. Furthermore,
RATMAP supports comparative mapping to several species. At present, comparative mapping data is
given for bovine, human and the mouse.
RIKEN Genomic Sciences Center
They have developed a unique system for synthesis of full-length cDNA
clones and have sequenced the 3'-ends in order to catalogue the 107,088
cDNA clones. Approximately 5,000 unknown partial sequences were
identified by comparing sequence data with the sequence data registered
in various human and mouse databases.
The Mouse UniGene Collection
Expressed sequence tag (EST) approaches have been used in
several organisms as a cost-effective means of identifying a
remarkable number of novel genes. In the mouse, over 400,000
EST sequences have been generated, primarily through an
initiative funded by the Howard Hugues Medical Institute and
carried out at the Washington University Genome Sequencing
Center. The Mouse UniGene collection is an attempt to partition
these ESTs into sets or "clusters" that correspond to distinct
mouse genes. The reduced accuracy and partial nature of ESTs
makes this a challenging task, but methods have been developed
to generate UniGene in a mostly automated fashion. The UniGene
set has proven useful for the selection of candidates for
high-throughput gene mapping and gene expression studies.
The German Mouse ENU Project
The German Human Genome Project has established a research
center to perform a large ENU mutagenesis screen in the mouse.
The research center consists of a core facility and several
associated laboratories. The core facility will generate
mutagenized F1 mice which will then be analyzed by the
associated laboaratories. Additional screens will be (can be)
performed by other research groups that are not participants of
the German Human Genome Project.
NIH Mouse Initiative Web site
In March 1998, the NIH convened a group of scientists to develop
priorities for mouse genomics and genetics resources. In response to
the community's recommendations, the NIH has created a Trans NIH
Mouse Genomics and Genetics Resources Coordinating Group and a
strategic implementation plan. For the convenience of all interested
investigators, we have established this Web site as a central
information resource. It will contain all relevant information from all
parts of the NIH, including summaries of the original planning
meetings, publications about the NIH action plan, funding
opportunities, progress reports, etc.
Mouse and Rat Research Home Page
This serves as a central place to find resources of particular interest
to scientific researchers using mice or rats in their work. In addition
to a somewhat exhaustive listing of especially useful internet
resources, you'll also find conference announcements and other
information.
Rat Strain Information and Lab Code Names
TBASE Transgenic and Targeted Mutation Animal Database
TBASE is a database of organisms (Mouse, Fruitfly, Pig) and gene
sequences which have undergone artificially introduced genetic
transformations. Data may be searched by accession number, animal, name
of line, method used, DNA introduced, genetic background, gene
expression, phenotype, integration site, notes, author(s) and citation.
Transgenic Systems for Mutation Analysis
This gives information on transgenic animals, in particular BigBlue and
MutaMouse, used for the study of mutations in mammals by means of a
recoverable mutation target gene.
ORNL Transgenic and Targeted Mutant Animal Database
This displays data which researchers have provided about their lines of
animals, therefore information that is not necessarily available from
published literature is found in the database. The Transgenic and
Targeted Mutant Animal Database is a powerful research tool which covers
topics including methods used to generate each line, a detailed
description of the DNA construct used, expression of the transgene or
targeted mutation, and the resulting phenotypes
Mouse Cytogenetic Map Image
This gives a clickable interface to the mouse chromosome ideograms.
Whitehead Institute/MIT Genome Center Mouse Genetic Map
This holds the latest release of the Whitehead Institute/MIT Center for
Genome Research mouse genetic map.
View genetic maps and physical maps with STS-content data.
Whitehead Institute/MIT Genome Center Rat SSLP Data
This consists of polymorphic rat microsatellite repeats mapped on a
SHRxBN F2 intercross using PCR probes. The average spacing between
markers on these maps is approximately 3.7 cM.
Any Comments, Questions? Support@hgmp.mrc.ac.uk